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The research described herein aims to add to the body of knowledge of program management and factors that lead to acquisition program terminations within the U.S. Department of Defense (DoD). Specifically, this research surveyed three groups—DoD acquisition program managers, defense industry program managers, and defense industry consultants—to evaluate and analyze key program factors that influence DoD acquisition program terminations. This research used relative importance weight calculations and a chi-squared distribution analysis to compare the differences between DoD acquisition program managers, defense industry program managers, and defense industry consultants regarding the factors that lead to DoD acquisition program terminations. The results of this research indicate that a statistically significant difference does not exist between the three groups as to the relative importance of 11 program management factors.